Adventure is waiting in San Antonio, Texas

Stay and enjoy something surprisingly different at the Sonesta ES Suites San Antonio Northwest – Medical Center. We’re conveniently located in the heart of the San Antonio - Medical Center area and just minutes from San Antonio International Airport. Just 13 miles from downtown San Antonio, 6 miles from Six Flags Fiesta Texas and a short drive from countless sites in the metro area, the Sonesta ES Suites San Antonio Northwest - Medical Center is the ideal hotel from which to explore the region, do business, and take in one of the largest cities in the U.S. Our welcoming staff is eager to share their local knowledge with you, whether you’re in search of an art-filled afternoon, water recreation sports or wine tasting excursions nearby in the Texas Hill Country. Our hotel is ideally located near the area’s most important healthcare facilities and businesses, including Methodist Hospital, St. Luke Baptist Hospital, University Hospital, UT Health Science Center, 3M, Accenture, Ernst and Young, USAA, UnitedHealth Group and more. Our spacious suites offer multiple bedrooms, fully equipped kitchens, complimentary on-site laundry machines and free Wi-Fi.


4320 Spectrum One

San Antonio, TX 78230 US

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Inspector's Best of Housekeeping 2021

Clean Rooms. Comfortable Hotel.


AAA Inspector's Best of Housekeeping - 2021

To earn the Inspector’s Best of Housekeeping Award, 77 Sonesta managed US hotels demonstrated housekeeping excellence for two consecutive inspections and were free of AAA member complaints.


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Stay Safe with Sonesta

We are committed to protecting the health, safety, and well-being of our guests and employees. Our Stay Safe with Sonesta program, in partnership with Ecolab, observes applicable public health requirements and enhanced hygienic protocols including cleanliness, sanitization, and modified guest services. Learn about our hotel and available amenities that reflect the current guest experience.