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Sonesta ES Suites San Francisco Airport Oyster Point Waterfront

Newly Renovated South San Francisco Hotel

Check-in: 4:00 PM
Checkout: 11:00 AM

Discover spacious suites and excellent value at the newly renovated Sonesta ES Suites San Francisco Airport Oyster Point Waterfront hotel. Our South San Francisco hotel suites feature a brand new fully equipped kitchen, roomy work area with new furnishings, free Wi-Fi, and plush new beds. In the morning, you will enjoy free hot breakfast with fresh coffee and a variety of offerings like breakfast tacos at our egg station. Looking to catch some rays or cool off? Enjoy our outdoor seasonal pool and hot tub. 
Stay less than a mile from leading biotech companies including Amgen and Thermo Fisher. Just a short drive away, you will find Genentech, UCSF Medical Center, and Kaiser Medical Center. 

Whether you’re here for business, leisure, or a long-term stay, our all-suite hotel has all you need to feel right at home and much more. 

Extend Your Expectations with Sonesta ES Suites. 

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Breakfast Reimagined

Breakfast Reimagined

Join us for a fresh take on free breakfast with pastries, pancakes, breakfast tacos, cereals, and more.

Get Together in San Francisco

Get Together in San Francisco

From sports teams to business conferences—easily book your group travel with us.


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Travel Agents: Visit our partner portal to book with your agent ID.
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Save More. Every Time.

Save More. Every Time.

Sonesta Travel Pass members always enjoy our best rates. Book the Sonesta Travel Pass Member Rate and receive perks on your very first stay.

3x Points on Updated Escapes

3x Points on Updated Escapes

Feels like the first time. Discover an all-new experience at Sonesta ES Suites San Francisco Airport Oyster Point Waterfront and earn 3x Travel Pass points on your stay.

Extend Your Stay

Extend Your Stay

Now’s the time to explore more, for less. Enjoy 7 or more nights with us at discounted rates when you book with code LONG.

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About The Hotel

Hotel Details

Discover Sonesta ES Suites San Francisco Airport Oyster Point Waterfront

Conveniently located near the offices of major biotech companies such as Amgen and Thermo Fisher, our newly renovated South San Francisco hotel offers easy access to a wealth of San Francisco area attractions.  

Our spacious and recently refreshed suites are designed with your comfort in mind with new furnishings and plush new beds. Each suite offers a fully equipped, remodeled kitchen where you can prepare a home-cooked meal at your leisure.  

Start your day with our delicious complimentary breakfast and savor a wide selection of morning favorites, from freshly brewed coffee to an array of delicious breakfast classics like pancakes and breakfast tacos.

Stay connected and productive during your stay with our complimentary Wi-Fi to effortlessly attend to business matters or share memorable moments with loved ones.

Whether you're visiting for business or pleasure, our friendly staff is committed to making your experience with Sonesta ES Suites effortless and unforgettable.