Sonesta ES Suites San Francisco Airport Oyster Point Waterfront
Newly Renovated South San Francisco Hotel
Discover spacious suites and excellent value at the newly renovated Sonesta ES Suites San Francisco Airport Oyster Point Waterfront hotel. Our South San Francisco hotel suites feature a brand new fully equipped kitchen, roomy work area with new furnishings, free Wi-Fi, and plush new beds. In the morning, you will enjoy free hot breakfast with fresh coffee and a variety of offerings like breakfast tacos at our egg station. Looking to catch some rays or cool off? Enjoy our outdoor seasonal pool and hot tub.
Stay less than a mile from leading biotech companies including Amgen and Thermo Fisher. Just a short drive away, you will find Genentech, UCSF Medical Center, and Kaiser Medical Center.
Whether you’re here for business, leisure, or a long-term stay, our all-suite hotel has all you need to feel right at home and much more.
Extend Your Expectations with Sonesta ES Suites.
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Fall Retreats, Double Rewards.
Sonesta Travel Pass members always enjoy our best rates. Book the Sonesta Travel Pass Member Rate and receive perks on your very first stay, including twice the points!

3x Points on Updated Escapes
Feels like the first time. Discover an all-new experience at Sonesta ES Suites San Francisco Airport Oyster Point Waterfront and earn 3x Travel Pass points on your stay.

Extend Your Stay
Now’s the time to explore more, for less. Enjoy 7 or more nights with us at discounted rates.
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Hotel Details
Discover Sonesta ES Suites San Francisco Airport Oyster Point Waterfront
Conveniently located near the offices of major biotech companies such as Amgen and Thermo Fisher, our South San Francisco hotel offers easy access to a wealth of San Francisco area attractions.
Our spacious suites are designed with your comfort in mind, featuring fully equipped kitchens where you can prepare a home-cooked meal at your leisure.
Start your day with our delicious complimentary breakfast and savor a wide selection of morning favorites, from freshly brewed coffee to an array of delicious breakfast classics.
Stay connected and productive during your stay with our complimentary Wi-Fi to effortlessly attend to business matters or share memorable moments with loved ones.
Whether you're visiting for business or pleasure, our friendly staff is committed to making your experience with Sonesta ES Suites effortless and unforgettable.