Sonesta ES Suites San Francisco Airport Oyster Point Waterfront
Sonesta ES Suites San Francisco Airport Oyster Point Waterfront

Welcome to Sonesta ES Suites San Francisco Airport Oyster Point Waterfront

Your Home On The Road

Welcome to South San Francisco

Discover spacious suites and excellent value at the Sonesta ES Suites San Francisco Airport Oyster Point Waterfront hotel. Our South San Francisco hotel suites feature a fully equipped kitchen, roomy work area with furnishings, free Wi-Fi, and plush beds. In the morning, you will enjoy free hot breakfast with fresh coffee and a variety of offerings like breakfast tacos at our egg station. Looking to catch some rays or cool off? Enjoy our outdoor seasonal pool and hot tub.

Stay less than a mile from leading biotech companies including Amgen and Thermo Fisher. Just a short drive away, you will find Genentech, UCSF Medical Center, and Kaiser Medical Center.

Whether you're here for business, leisure, or a long-term stay, our all-suite hotel has all you need to feel right at home and much more.

Extend Your Expectations with Sonesta ES Suites.

Get exclusive member rates
Free Breakfast
Free Breakfast
Tier Bonus Multiplier
Tier Bonus Multiplier
Free Rooms Upgrades
Free Rooms Upgrades
Premium WI-FI
Premium WI-FI
Discover Sonesta International Hotels

Discover Sonesta International Hotels

At Sonesta International Hotels, We Open Our Doors And Welcome The World.

With over 1,100 properties in eight countries and 13 industry-leading brands to choose from, whether you're looking for luxury, homelike experiences, or budget-friendly adventures, we have a Sonesta stay that's perfect for you.

Explore More

Adventure Bound

Let us inspire your next adventure

View All Experiences
How Two Hotel Chefs Would Host Thanksgiving at Home

How Two Hotel Chefs Would Host Thanksgiving at Home

Executive chefs Rakmin Lee and David Mahady share their Thanksgiving countdown, turkey brining method, and single-oven plan for hosting at home.

View More
Winter Magic at The Royal Sonesta Chase Park Plaza: A Two-Night Holiday Getaway in St. Louis

Winter Magic at The Royal Sonesta Chase Park Plaza: A Two-Night Holiday Getaway in St. Louis

Ahh, a winter getaway! The lights are up, the air is crisp, and time slows down. It’s time to build a trip around cozy moments – with family, a partner or friends. St. Louis is the place to do it. In colder months, the city comes alive with glittering light displays, outdoor skating, and neighborhoods

View More
New York without the Manhattan Hotel Stay – The Regional Visit You Didn’t Know You Needed

New York without the Manhattan Hotel Stay – The Regional Visit You Didn’t Know You Needed

Are you sitting down? I have big news. New York is more than Manhattan. I know! Who would have thought?! Sure, the crowded streets, sleepless nights, city lights, entertainment and attractions are great, but might I propose an alternate New York getaway and Hotel stay? I promise to include iconic city experiences in the journey.

View More
More Than a Stay: How The Royal Sonesta Washington, DC Dupont Circle and Capitol Hill Is Supporting Kidney Transplant Families

More Than a Stay: How The Royal Sonesta Washington, DC Dupont Circle and Capitol Hill Is Supporting Kidney Transplant Families

When travelers think about visiting Washington, DC, they picture monuments, museums, and embassy-lined streets. For some visitors, though, the trip has a very different purpose: a kidney transplant, a living donation, or the follow-up care that comes with both. Through a new relationship with the National Kidney Foundation (NKF), The Royal Sonesta Washington DC Dupont

View More